Authors: Nader Butto
Understanding fundamental biological mechanisms at the molecular, cellular, tissue, and organ levels provides the basis for formulating new theories of disease causation. This article presents a new theory of stress intensity and type of disease in the same organ with reference to the four phases of life (i.e., excitation, expansion, contraction, and relaxation). The intensity of the stress is determined by the balance between the intensity of the stimulus and the subjective capacity to cope with it. In acute stress, the intensity of the stress may be provoked by one of the four grades of fear (i.e., anxiety, fear, panic, and horror), which are related to the four phases of life. When a traumatic conflict is unresolved, the stress becomes chronic. In such cases, the response patterns follow four phases of reaction to chronic stress (i.e., alarm, resistance, adaptation, and exhaustion), that may become maladaptive and damaging. Both acute and chronic four-phase reactions are related to the four phases of life; their blockage results in disease. The type of disease in the organ is determined by the blocked phase. The right or left side of the body, meridian, or organ depend on male-female sex involvement, where the right and left sides are related to conflicts in males and females, respectively. The embryological germ layer-derived tissue depends on three possible trauma perceptions: 1) when a sense of threat of survival is felt, the endoderm tissue derivative is involved; 2) if there is a sense of lack of support, the mesoderm tissue derivative is involved; and 3) when there is a sense of separation, the ectoderm derivative tissue is involved. This new theory represents the base for a new disease classification that may assist researchers in identifying novel treatment targets, and developing innovative strategies for the prevention, diagnosis, and treatment of disease.
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