Authors: Nutchanat Nonsee, Watcharin Yingsitsiri, Bang-on Kidhen, Sutthinan Chawalchitiporn.
Introduction: Blood Collection Unit of Maharat Nokhon Ratchasima Hospital, Thailand, have intention to increase efficiency of Single Donor Platelets (SDP). The SDP donor pre-count found highly for select to be double dose plateletpheresis (DDP). By two principle (intermittent with the Universal Platelet Protocol (UPP) and continuous flow) of platetetpheresis systems in this study.
Objective: This study aimed to compare efficacies and cost evaluation of DDP in Platelet Additive Solution (PAS).
Materials and Methods: Intermittent flow systems: Hemonetics MCS plus / UPP®, HAEMONETICS Braintree, MA,U.S.A.(I) and continuous flow system: Trima Accel®version 7.0, Terumo BCT, Lakewood, USA(II) were plateletphereis with the same donor (platelet pre count >280,000 cells / μL). Data of pre and post hematological characteristics of donors, completed process, quantity and quality of DDP, satisfaction’s questionnaire, including margin cost were record. The data analysis test by T-test.
Results: DDP donor (N=30) found no statistically significant in hematological pre and post donated (p>0.05). Post donation found I has hematological characteristics less than II significantly (p<0.05). The duration process found statistically significant (p<0.05). DDP quantity found; I and II can collect platelet yield average 6.2x1011 and 6.5x1011 cells, respectively. Residual white blood cells (rWBC) found I less than II (p<0.05). pH and swirling phenomenon were not different (p>0.05). A,B and O blood group were low titer 66.6%, 100% and 91%, respectively. DDP with PAS found 100% low titer. The overall satisfaction rate; II higher than I (p<0.05). Percentage of the adverse reaction found numb lips, pain in phlebotomy site and dizziness; 90%,1.3% and 0.5%, respectively. The economic impacts found II system has positive profit from margin cost (+7,440 to 9,756 THB).
Discussion and Conclusion: The DDP donated by II have higher platelet yields than I. DDP in PAS useful for ABO identical platelets and provide without blood group specificity (100% low titer). PAS will increase patient safety by reduce the allergic reaction and febrile non hemolytic transfusion reaction. The percentage of collection efficiency (%CE) >60%, I=71.2%,II=73.6%. The PC prepared from a large amount of WB (>150,000 units in 2017-2019). DDP in PAS should be run in routine to allocate budgets to be worthwhile.
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