Authors: Saganuwan Alhaji Saganuwan.
About one third of diabetic patients develop diabetic foot problems that may originate from peripheral neuropathy and or peripheral neurovascular disease. Because of chronic and difficult to treat nature of diabetic foot ulcers, there is need for literature search with intent to understanding neuropathic and neuroischaemic nature of diabetes in order to control, prevent and treat diabetic foot ulcers. Findings have shown that inhibitors of aldose reductase, sorbitol dehydrogenase, activation of protein kinase C, activators of nitric oxide synthase, myo-inositol bisphosphatase, and other enzymes that play different roles in polyol pathway of diabetic neuropathy are the key points to prevention, control, management and treatment of diabetic foot ulcers. The use of central nervous system acting drugs, potent antimicrobials and traditional antidiabetics are complementary to holistic permanent cure of the disease. More potent antidiabetic ulcers could be synthesized from varieties of heterocyclic compounds reported in many journals of organic, pharmaceutical and medicinal chemistry. Therefore, successful treatment of diabetic foot ulcers is multimodal, but the major key success is constant adequate control of blood sugar.
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