Journal of Medical & Clinical Research & Reviews


Differences of IL-1 Levels and Degree of Histopathological Injury on Contralateral Testicle of the Rat (Rattus norvegicus Wistar strain) Undergoing Orchidectomy and Orchidopexy due to Testicular Torsion Contralateral Testicle of the Rat (Rattus norvegicus Wistar strain) Undergoing Orchidectomy and..

Pratiwi Dian, Purnomo Basuki B, Daryanto Besut.

Background: Testicular torsion is a growing urological emergency in the puberty age and early adulthood period. Treatment procedures include surgical detorsion and bilateral orchidopexy through trans-scrotal access, with orchidectomy indicated only for cases with unviable reperfusion after detorsion, or necrosis.

Objective: This study aimed to determine the differences of IL-1 levels and the degree of histopathological injury to the contralateral testicle in rats undergoing orchidectomy and orchidopexy due to testicular torsion. 

Methods: Wistar rats were divided into four groups: negative control, testicular ischemia for 6 hours followed by orchidectomy, testicular ischemia for 6 hours without being followed by orchidectomy, reperfusion for 3 hours followed by detorsion and repositioning the testicle in the scrotum. After 24 hours, rats were observed and the effects of each procedure on the contralateral testicle are observed by looking at the IL-1 levels and histopathology of the contralateral testicle. Statistical test are performed using one-way ANOVA and Tukey test for IL-1 and Kruskal-Wallis test and correlation Lambda for histopathological injury.

Results: There were significant differences in the group without orchidectomy compared to control group and the group undergoing orchidectomy, with value of p<0.05.

Conclusion: The testicle that experiencing testicular torsion would affect the damage of contralateral testicular through increased levels of interleukin-1 and increased histopathological injury.

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