Authors: Nagay AV, Khamidullayeva GA, Srojidinova NZ, Tursunova NB, Nagaev SJ and Usarov AR
Objective: CDS system testing on the example of the existing software of GS CDS: Some common mistaken in early design stage.
Design and Method: Architecture - Opened, multiplex platform. Encryption- Advanced Encryption Standard AES. Data transmission- Fiber optic link,WLAN. Type of interaction- Triangulation: CDS, EMR, DNA database.
Results: We recommend to consider several moments on the first steps of projection. In - the first to pay attention to an analytical stage. It is necessary to consider in advance all working platforms which will be served by CDS. Use Bayesian approach to frame a matrix of recognition of the damaging alleles and haplotype. It is necessary to adhere to standard forms of biological data. To strengthen enough genetic information, CDS has to be able to structure a superfine phenotype. For stratification of risk of rising of the ABP (the high, increased, average risk) use multi-sample option. It will lead to specificity increasing while sensitivity will remain invariable. Use heuristic and statistical algorithms; they will be able to identify the damaging genotype, without conflicting to clinical information of the patient.
We have also found dominance of European contribution (83%) to the development of hypertension/pre-diabetes. Heritage of hypertension in Uzbek population has been evaluated as 17% Eastern, 33% Southern, 25% Central Europe, 8% for Anatolia and 17% for South East Asia. The functional significance of all 12 genes in hypertensive patients with combination of atherosclerosis and pre-diabetes is similar for the most part with European type of heritage. However, a distinctive sensitivity to the exchange of sodium in these individuals is due to 17% of the Asian contribution.
Conclusions: When an analysis is carried out, any acceptance or rejection must follow clearly defined rules. According to our study we suggest that applying the CDS technology as a first step within a diagnostic algorithm it is possible to increase the diagnostic accuracy reducing the rate of biological ageing of vessels. We have also found dominance of European contribution (83%) to the development of hypertension/pre-diabetes. Perhaps this similarity in hypertension/pre-diabetes lineage between Uzbek and European populations, due to the fact that the ancient settlements of the Paleolithic Age could migrate to Central Asia from the east and west, not from north and south.
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