Diabetes & its Complications

Abstract

Diabetes Mellitus, HbA1c, and Lung Function: Do they are Related?

Mee-inta, Anongnad, Rojwipaporn Chanaporn, Ngernrot Anuttra, Butpeng Parnjai, Kaewthamma Peeranutt.

Introduction: Diabetes mellitus (DM) is a chronic disease which frequently found in the world population. Complications of diabetes mellitus can lead to other comorbidities and mortalities. Pathology of its can cause microangiopathy in alveoli which has contribute to restrict lung volume, capacity, and change in pulmonary functions. However, little is known about the mechanisms of lung dysfunction and there is controversial about relation between duration of diabetes, HbA1c, and pulmonary function in patients with type 2 diabetes mellitus.

Objective: The objective was to evaluate the correlation between duration of diabetes, HbA1c, and pulmonary function in patients with type 2 diabetes mellitus.

Methods: A cross-sectional study was conducted at Somdet Prayannasungworn Hospital, Chiang Rai, Thailand. Forty participants had diagnosed of type 2 diabetes mellitus from physician, both men and women, and age 
between 40-70 years old. They were interviewed for demographic data and duration of diabetes and tested HbA1c and pulmonary function tests (PFTs) from trained physical therapist. Forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and ratio of FEV1 and FVC (FEV1/FVC), and forced expiratory flow at 25- 75% (FEF 25-75%) were measured by spirometry. The Spearman Rank Correlation was used.

Results: Diabetes duration was statistical significantly negative correlated with forced expiratory volume in one second (FEV1) (r =- 0.323, p-value<0.05) and forced vital capacity (FVC) (r = - 0.349, p-value < 0.05) while HbA1c was not correlated with pulmonary function.

Conclusions: Diabetes duration was significant associated with pulmonary function reduction in DM patients. However, relationship between HbA1c and pulmonary function in patients with type 2 diabetes mellitus were not found in this study.

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