Anesthesia & Pain Research

Abstract

The Efficacy of Magnesium Sulfate in Reduction of Post Cardiac Surgery Arrhythmia, Agitation and Pain: A randomized controlled study.

Mohamed Ahmed Hamed, Farhan Saleh Farhan.

Background: Arrhythmia, postoperative pain and agitation are a common complication after heart surgery and are a major source of morbidity and mortality.

Aims: This study aimed to study the efficacy of magnesium sulfate (MgSO4) for reduction of post cardiac surgery arrhythmia, postoperative pain and agitation.

Setting and Design: This study design was a prospective randomized controlled double blinded clinical study.

Patients and Methods: 140 adult patients that underwent elective cardiac surgery were randomized into 2 groups, Mg group (group magnesium), 70 patients received 30 mg.kg-1 MgSO4 in 500 cc normal saline and in group C (control group), 70 patients received 500 cc normal saline alone.

Statistical Analysis used: Mann-Whitney’s, Chi square, Friedman’s, factorial ANOVA, logistic and multiple regression analysis were used.

Results: Comparative study between the 2 groups revealed; significant decrease in arrhythmia events in Mg group; compared to control group; with significant statistical difference (p=0.023). The 2 groups showed marked decrease in VAS scores in Mg group; compared to control group; during the serial measurements. Comparative study between the 2 groups revealed non-significant difference as regards RASS score (p>0.05).

Conclusion: Mg significantly decreases the incidence of all type of postcardiac surgery arrhythmia and decrease the severity of postoperative pain and agitation

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