Ophthalmology Research


Anatomical and Functional Response to Topical Carbonic Anhydrase Inhibitor in X-linked Juvenile Retinoschisis (XLJR)

Tatianne Fernandes Duarte , Luciana Ferreira Brina, Jacques Ramos Houly, Leticia Alves Oliveira do Carmo, Marcela Caetano Bastos, Maria Mercês Amaya Gutierrez.

The authors report the anatomical and functional response to topical use of carbonic anhydrase inhibitor (CAI) in the treatment of foveoschisis in a case of X-linked juvenile retinoschisis (XLJR). A 9-year-old boy with visual impairment in both eyes, was admitted to Hilton Rocha Fundation ophthalmologic clinic. Fundus examination revealed radial cystoid appearance in a petaloid configuration in the fovea, and retina pigment epithelium alterations at superior mid-peripheral retina in both eyes. Optical coherence tomography (OCT) showed foveal cystoid structures, loss of foveal depression and splitting at inner retinal layers in the macula. Following treatment with topical dorzolamide 2% for 7 months, there was dramatic regression of both macular and peripheral schisis
cavities and improvement of visual acuity in both eyes.

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