Stem Cell and Regenerative Medicine

Abstract

Mesenchymal Stem Cells X Lateral Amyotrophic Sclerosis - Las

Décio Basso

The mesenchymal stem cells can be expanded ex vivo and are capable to differentiate in several lineages, represent a rare subpopulation of the bone marrow cells (< 0, 01% of the mononuclear cells of bone marrow) with mitotic expansion capacity in vitro. As a result of the facility in dividing and proliferate, we concluded that the mesenchymal stem cells would be responsible for the maintenance and renovation of adult mesenchymal tissues. This cell type presents as one of its virtues a considerable immunomodulatory activity, avoiding any adverse effects. We believe that, overcoming some challenges in its isolation, preparation and infusion mode, due to these characteristics, the MSC represent promising tools for cell therapy, mostly the ones associated to bone marrow transplantation. The amyotrophic lateral sclerosis (ALS) still is a disease of unknown cause nowadays, despite knowledge of many of its aspects have advanced since Charcot’s epoch. Many theories were proposed for its pathogen; however, none of them has showed unifying until now. These would have to explain the different degrees of incidence in several geographic areas, the distinct forms of clinic presentation, time of evolution, as well as the vulnerability and resistance of determined neuronal populations. It is possible that we are in front of many anatomical-clinical entities of multiple etiologies, which are presented in a similar form. This work showed that MSC cultures can be obtained starting from samples of bone marrow of healthy donors through standard of processing protocols, cultivation and characterization in vitro, and even of autologous donors.

View pdf