Authors: Machibya Ferdinand Mabula, Chen Jiang.
Purpose: To evaluate the effects of bone regeneration materials (BRMs) and orthodontic tooth movement (OTM) on radiological features as well as receptor activator of nuclear factor-κBligand (RANKL) and osteoprotegerin (OPG) concentrations in gingival crevicular fluid (GCF).
Methods: Twenty-four alveolar bone defects in beagle dogs were treated using either Bio Oss® or beta-tricalcium phosphate (β-TCP) (experimental) with empty control defects. The concentrations of OPG and RANKL inGCF were examined by immunoassay analysis, while the tooth displacement and alveolar bone height after OTM were radiographically assessed
Results: After OTM the second premolar displacement for Bio Oss was statistically significantly lower than control group and theOPG concentration at baseline was significantly higher in the control than the Bio Oss group. The β-TCP group registered statistically higher RANKL concentration than control and Bio Oss groups at the end of orthodontic tooth movement.
Conclusions: The type of regeneration materials used determined the extent of tooth movement in regenerated alveolar bone defects. Whereas, orthodontic force as well as the type of BRMs affectedthe RANKL and OPG concentration in GCF.
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