Authors: Min Kyu Kim
Purpose: Hereditable cancer syndromes are mostly known by MMR(mismatch repair gene) based Lynch syndrome and BRCA gene -based hereditary breast and ovarian cancer (HBOC). There are difficulties for making selection process suitable for different groups to the final confirmation testing according to ethnicity and country. Acceptance and approval chances also are inconsistent according to cancer counseling initiation period. Our study objective was to investigate the feasibility hereditary gynecologic cancer clinic establishment using available cancer genetic counseling and tests approved by a surgeon among patients with gynecologic malignancies in Korea.
Methods: We included 30 patients of ovarian and endometrial cancers until refusal of genetic tests after counseling calendrically. Early cancer genetic counseling was given to patients with information of immunohistochemistry (IHC). Final genetic sequencing to prove germline mutations was done after patient consent for suspicious candidates.
Results: This study included 19 ovarian and 11 endometrial cancer patients. We obtained negative IHC results for MLH1, MSH2, BRCA1, and BRCA2.They were 0 (0%), 2 (7%), 14 (52%), and 3 (11%), respectively. Three patients (10%) had germline mutations (two BRCA and one MMR mutation).
Conclusion: Our study shows that surgeon has a favorable position to implement hereditary cancer clinic among gynecologic malignancy patients in well-equipped community hospital.
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