Authors: Nouhoum Diarra, Hervé Traoré, Mamadou Abdoulaye Konaré, Issiaka Togola, Cheickna Daou, Yaya Bouaré, Mahamadou Samaké.
In 2017, an estimated 21.7 million people living with HIV had access to antiretroviral treatment. Many biochemical variations are related to diet but also to the side effects of ARVs. The objective of this work is to describe variations in some biochemical parameters (transaminases, creatinemia and blood sugar) in patients living with HIV (PLWHIV) on antiretroviral therapy (ART). This was a retrospective study of 201 PLWHIV over the period October 2018 to January 2019. Only PLWHIV on ART who were at least 18 years old and had a biological check-up at one of the following periods: at treatment initiation (M0), at 6, 12, 18, 24 and 30 months were considered. Patients' transaminases, creatinemia and blood sugar levels were measured by the spectrophotometric method. The results showed that out of 201 patients, women represented 70.15% of the study population compared to 29.85% of men. The study showed that 6.48% of patients had higher than normal blood glucose levels. 14, 28% of men and 17.41% of women had high creatinemia. Aspartate amino-transferase (ASAT) was high in 40.91% of cases in men and 35.82% in women. Alanine amino-transferase (ALAT) was high in 11.42% of cases in men compared to 21.92% in women. It appears from this study that the use of ARVs in PLWHAs seems to have had a negative impact on the biochemical parameters measured, especially ASAT, hence the importance of regular and constant follow-up in these patients.
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