Shigeaki Masuda, Mitsunori Ikeda.
Multikinase inhibitors can cause Hand-Foot Syndrome. In order to reduce the risk of Hand-Foot Syndrome caused by multikinase inhibitors, it is important to prevent hand roughness. Preventing drying can help avoid rough hands. The purpose of this study was to determine the protective effects of Vaseline application along with the use of polyethylene gloves while sleeping on healthy hands, which aim to enhance moisture in the skin. This study was conducted with the approval of the Ethics Review Board of the University of Kochi. There were 28 subjects (4 males and 24 females) aged 24 to 65 years (mean ± SD: 44.25 ± 6.82 years old). The moisture measurement sites included the palms (pads of the index fingers and thenars) and the dorsal part (the center part of dorsal side of the hand). Each site was measured using the Mobile Moisture HP 10-N, a capacitance-based sensing device, before the intervention. After a week, the same sites were measured in the same way. The change of skin moisture on each site before and after intervention was measured. No significant difference was observed in the skin moisture in the pads of the index fingers before (18.99 ± 11.67) and after (21.10 ± 12.72) the intervention. The mean values of the points of thenars (23.10 ± 12.28) after the intervention were significantly higher than the point of thenars (19.33± 9.29) before the intervention. The mean values of the center of dorsal side of the hand (24.11 ± 11.18) after the intervention were significantly higher than the points of the center of dorsal side of the hand (19.24 ± 9.40) before (p < 0.01). As a result of applying Vaseline and wearing polyethylene gloves while sleeping, it was recognized that the thenars and center parts of the dorsal side of the hand retain moisture.View pdf