Authors: Attapon Cheepsattayakorn, Ruangrong Cheepsattayakorn, Porntep Siriwanarangsun.
Hypothetically, mRNA-vaccine-encapsulated-small liposomes and lipid carriers may accumulate through the permeation retention and enhanced effect in tumor tissues. The recommendation that have been suggested administering COVID-19 vaccines one to two weeks prior to a chemotherapy dose by many key-professional organizations has not been practical with COVID-19 administration schedules (for examples; two doses of mRNA1273 (Moderna) are recommended to be given 28 days apart, whereas two doses of BNT162b2 (Pfizer/BioNTech) are given 21 days apart, efficacy > 94 %), variable chemotherapeutic regimens, and limited COVID-19 vaccination slot availability, contributing to allowing the most rapid COVID-19 vaccination of these immunosuppressed cancer patients and due to lacking COVID-19- vaccine safety and the information immunogenicity in the context of immune-system-stimulated immunotherapies (for examples; immune checkpoint inhibitor (ICI) therapy) and general exclusion of malignancy-diagnosed patients in the clinical trials of currently approved COVID-19 vaccines.
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