Authors: Melissa Wasilewski, Sara Kwiatkowski, Kunal Kapoor, Sumon Roy.
The tendency of macrolide antibiotics to prolong the QT interval in certain patient populations is well documented. In contrast, limited reports exist of medication-induced deep T-wave inversions. We recently encountered a case of azithromycin-induced QT prolongation with concurrent deep TWI, an association that is rarely observed in clinical practice. As similar ECG changes can be seen with life-threatening conditions such as coronary ischemia and cerebral hemorrhage, comprehensive workup to rule out acute pathologies is critical when this pattern is recognized.
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