Authors: Ming C. Liau, Linda Liau Baker.
Solution of cancer was obviously an important national interest for President Nixon to declare ‘War on Cancer” in 1971. Health professionals failed the challenge to put cancer away during the 5 years of intensive presidential support and in the following 46 years of exclusive medical support allocated to cancer. Cancer stem cells (CSCs) stood in the way to deny the success of cytotoxic agents, the choice of cancer establishments in the past, to put cancer away. Cancer arises due to wound not healing properly. Consequently, the process of wound healing is the most appropriate modality of cancer therapy. Cytotoxic agents creating wounds are apparently contra-indication on cancer therapy. Cytotoxic agents are, however, the most effective agents to eliminate the most outstanding feature of cancer, namely the perpetual replication of cancer cells (CCs). A critical mechanism of wound healing is the induction of terminal differentiation of progenitor stem cells (PSCs) which are the precursors of CSCs.
Wound healing metabolites active as differentiation inducers (DIs) and differentiation helper inducers (DHIs) are required to direct the terminal differentiation of PSCs to heal the wound. Cell differentiation agent (CDA) formulations are preparations of wound healing metabolites most fit to take out PSCs and CSCs by directing these cells to undergo terminal differentiation, which are protected by drug resistance and anti-apoptosis mechanisms, thus unresponsive to cytotoxic agents. CDAs alone or in combination with cytotoxic agents become perfect drugs to take out both CCs and CSCs, and to restore the functionality of chemo-surveillance necessary to win the war on cancer.
View/Download pdf