Authors: Chang CT, Liu CM, Yeh HC, Li WJ, Li HT, Chen CY, Liu SL.
The human influenza virus and avian influenza virus represents a serious threat to human health. Although zanamivir and oseltamivir against influenza virus neuraminidase and thus the viral replication is not available. The oseltamivir-resistant H5N1 virus has been isolated from patient. Moreover, several cases have been reported where patients developed adverse symptoms due to a long-term use of oseltamivir. Effective antiviral drugs are essential for early control of an influenza pandemic. Natural products have been used as important resources for medicine and healthy food to improve the quality of life. Cinnamon bark is widely used as a spice and herb medicine. In this study, we have isolated and identified three butanolide derivatives, kotomolide A, isolinderanolide B and linderanolide B from Cinnamomum kotoense and Cinnamomum subavenium. Further, enzyme-based screening and anti-viral activity were also examined. Our study provides a starting point for developing new therapeutic or preventive agents from natural products for avian influenza virus.
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