Cancer Science & Research

Open Access ISSN: 2639-8478

Abstract


The Role of Mutations Genes NPM1, FLT3, DNMT3A, CEBPA, IDH1& IDH2 in Cytogenetically Normal Acute Myeloid Leukemia

Authors: Saeed Heidarisani, Mohammad Yazdani, Hediyeh Hosseini, Shahin Asadi.

Cytogenetically normal acute myeloid leukemia (CN-AML) is a type of hematopoietic tissue (bone marrow) cancer called acute myeloid leukemia. In normal bone marrow, early blood cells called hematopoietic stem cells develop into several types of blood cells: white blood cells (leukocytes) that protect the body against infection, red blood cells (erythrocytes) that carry oxygen and platelets (thrombocytes) play a role in blood coagulation, in acute myeloid leukemia, the bone marrow produces a large number of abnormal and immature white blood cells called myeloid blasts. Instead of becoming normal white blood cells, myeloid blasts turn into blood cancer cells.

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