Authors: Marakhouski Y, Rubens Juris.
First of all, the protection of gastro mucosa against injury, which can be caused by a variety of noxious agents, and the restitution of mucosal integrity after mucosal damage depends on the interplay of numerous different effectors and mediators. Second. The mucus is the first line of defense against luminal attacks on mucosal integrity. The intact microcirculation which is necessary for tissue protection and repair. Thirdly, the process of mucosal restitution and regeneration is controlled by various endogenous components, including growth factors, particularly EGF and TGFα. Fourthly, some agents which can cause mucosal damage like non-steroidal anti-inflammatory drugs, including acetylosalicylic acid, and probably can be protected by natural substances via the mechanism of adaptive gastroprotection.
Essential is the presence of a series of exogenous natural substances that have a gastroprotective effect, increasing the gastric mucosa endogenous adaptive cytoprotection potential. Among such exogenous natural substances, we paid attention to the Coniferous Pine Needles Extract (Baltic pine or Pinus sylvestris). The phytochemical substances present in Coniferous Pine Needles Extract are nontoxic at therapeutic levels, with clearly gastroprotective effect.
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