Authors: Suchmacher Mendel, Geller Mauro.
The authors report a case of transitory polyglobulia and low platelet count associated with Pfizer mRNA vaccine administration. Upregulation of heme, beta- and gamma-globin synthesis due to activation of NFR2 by IRP/ synthetic mRNA/eIF4E complex and decreased immune-mediated megakaryocytopoiesis and/or peripheral platelet destruction, were hypothesized mechanisms.
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