Diabetes & its Complications

Open Access ISSN: 2639-9326


Clinical Study to Determine Efficacy of Trigonella Foenum-Graecum Extract in Patients with Type 2 Diabetes

Authors: Gupta RS, Grover AS, Apurva Goel, Kiran Tiwari.

The anti-diabetic action of Fenugreek seeds is known to be effective by enhancing insulin sensitivity as well as reducing insulin resistance along with decreased glucose absorption. Trigonella foenum-graecum extract has been shown to exhibit potent antioxidant, hypoglycemic, nephroprotective, and cardiovascular activities. It serves as an excellent membrane stabilizer mainly because of its active ingredient, novel furostanolic saponins.

The aim of the study was to determine the efficacy of fenugreek seeds extract in Type 2 diabetic patients. An open labeled, two armed and single-centric study on 104 Type 2 diabetic patients was conducted using a novel fenugreek seed extract for a period of 12 weeks to determine its efficacy in diabetic patients in management of glucose metabolism.

The results showed that Trigonella foenum-graecum extract caused significant reduction in fasting glucose, Post Prandial glucose levels as well as in HbA1C levels. Fasting blood glucose levels were decreased in 95.2% of the study population.

As observed on completion of the treatment with Trigonella foenum-graecum extract, 88.10% of study population was shown to have decrease in PP glucose levels. The HbA1c levels came to normal range (Good control range - 4.5-6.3%) in almost all of the study population whereas these were still abnormal (Poor control levels – 7.6%) in on-going anti-diabetic therapy treated population after 12 weeks of treatment.

No significant changes were observed in liver function tests, urea and creatinine levels and hematological parameters.

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