Authors: Mary Odejayi-Shotunde, Rezoun Shafiullah, Bibodh Jung Karki SM, Somaya Abuelazm, Rimsha Ashfaq, Mehreen Qureshi, Deepti Sanghavi, Muhammad Imran
Background: A Systematic review is defined as a type of literature review which critically appraises and synthesizes the best existing prove to initiate a study of conclusion by means of resolving specific clinical issues. Therefore, this study is a systematic review which determines the pathogenesis of depression and correlation with suicidal ideation and its relationship with occipital lobe as well as establishing a preventive measure for depression and suicidal ideation in children of pediatric age group as well as the adolescent.
Objective: Suicidal ideation is common among pediatric age group with depression worldwide and has been known to be the most leading cause of suicidal ideation, this article has been narrowed down to investigate the link between occipital lobe and neurobiology factor in patients with depression and successful suicidal attempt within past. Five (5) year of study.
Method: A systematic assessment of the electronic comprehensive article was conducted July 2018 using various databases, PubMed, Medline, Cochrane Library and Psych INFO listing articles with keywords; depression, suicide, occipital lobe, Serotonin reuptake inhibitors (SSRIs), HPA axis, neurotransmitters and finally 50 relevant studies were extracted from PubMed database. The quality of systemic review was evaluated with the use of Assessment of
Multiple Systematic Reviews (Mod-AMSTAR) tool, formed on the AMSTAR scale including the PRISMA Checklist.
Result: Memory display a substantial role in the risk of suicidal acts in the same vein, defects in cognitive inhibition has been linked with the inferior frontal gyrus, thalamus, orbitofrontal cortex and parietal cortex leading to depression and the aggravations predisposes to suicidal ideation.
Conclusion: Our finding has given us fact and hypothesizes that state-related defects may predispose to trait-like cognitive impairments to facilitates to suicidal vulnerability, which may impose various therapeutic approaches for the prevention of suicidal attempts, further brain damage as well as PTSD in pediatric age groups and adolescents.
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