Authors: Tina Zhang, Lee Chen, Monica Lui, Xiao Chen, Wen Ying Lee, Jonathan Tang, Pei-Ju Chu, Tom Flashman, James Wang.
In this study, we find a subject with a deficiency of IL-1 receptor antagonist (DIRA) – like syndrome who also has symptoms similar to that of psoriasis. Within 24 hours of intravenous infusion with autologous SB cells®, the subject’s IL-1 RA expression is shown to increase drastically, during which the subject experiences relief from his psoriasis-like symptoms.
The subject was diagnosed with psoriasis as a young adult; however, no treatment has offered relief for the psoriatic plaques located along his forearms and back. Currently his diagnosis is classified as psoriasis and his management of the disease is minimal. Throughout the course of SB cell® treatments, we used ELISA to monitor a panel of cytokines, it was here we noticed the subject’s deficient IL-1RA expression without treatment, his expression levels were near 0 pg/ml. 24 Hours after treatment, measurements of his expression levels were increased several thousand fold.
This case presents the possibility that SB cells can act as a treatment for psoriasis due to IL-1 RA deficiency.
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