Africa hosts nearly seventy-five percent of the world's youth population, positioning the continent as a future hub of the global labor force. However, the rapid emergence of digital technologies associated with the Fourth Industrial Revolution (4IR), Fifth Industrial Revolution (5IR), and the anticipated Sixth Industrial Revolution (6IR) has created a widening skills gap between technological advancement and youth preparedness. This paper argues that coordinated intervention by churches, businesses, and governments is essential to equip African youth with digital and technological competencies required in the evolving global economy. Drawing on insights from ergonomics and human factors theory, the study proposes a collaborative framework for youth up-skilling and re-skilling that integrates ethical formation, technological literacy, and social responsibility. The paper concludes that multi-sector partnerships can contribute significantly to reducing unemployment, poverty, and inequality while preparing Africa's youth for participation in future digital economies.