Huge advancements in the field of cosmetology and numerous methods of skin restoration have kept the studies of skin aging continually relevant and up-to-date. Age-related changes in the physiological parameters of skin cover might be related to a trophic innervation disorder, which, in its turn, is caused by aging manifesting itself in the corresponding structures of the vegetative nervous system.

The present article aims at describing this particular skin aging mechanism. Reduction of the amount of cells in n. sensorius superior of the trigeminal nerve has been proven to be connected with a decrease in the amount of cells in the innervated areas of skin.

The research was undertaken using autopsy material from people of various age groups who died from cardiovascular and cerebrovascular diseases. There has been an additional study of immunohistochemical expression of Ki-67 in order to assess functional condition of skin cells and calculate the proliferation index.

Studying proliferation index of dermal cells with the help of assessment of Ki-67 expression has shown that fluctuations in the proliferative activity have no direct dependence on the age.

It is obvious that the correlative relationship between changes in the nuclei of the trigeminal nerve and the development of atrophic processes in the innervated skin areas is much more expressed when compared with age correlations.

Reduction of the amount of cells in n. sensorius superior of the trigeminal nerve may be considered one of the mechanisms of aging realized as a systemic phenomenon.