Leishmaniasis is one of the most common tropical diseases worldwide. There are three main forms of leishmaniasis: visceral, the most severe; cutaneous, the most common, which generally causes skin ulcers; and mucocutaneous. We reproduced the disease by inoculating the plantar pad of BALB/c mice with the species Leishmania mexicana. No morphological studies have defined or identified the histopathological nature of this murine model; therefore, we decided to study and describe it using histological, immunohistochemical, and immunofluorescence techniques. We found that it is a lipoma in which adipose tissue is an important histological component, and in this case, it is populated by Leishmania mexicana in its amastigote form. Generally, we know that adipose tissue performs metabolic functions such as energy storage, which leads us to recognize the role it plays in the reproduction and migration of the parasite. To reinforce these histopathological studies, we also inoculated the parasite at the base of the tail of these mice, which strengthened our results, as it turned out to be the same morphological description as that of the plantar pad model, where adipose tissue is a visibly important element. With these results, we suggest that adipose tissue be added to the Leishmania spp life cycle.