Background: The elimination of tuberculosis is an increasingly common theme. This study describes the screening and management strategy for latent tuberculosis infection at SCL, with the aim of strengthening the efforts of the health authorities in the eradication of tuberculosis in Senegal.

Methods: We have described part of the overall public strategy for combating tuberculosis in SCL. An electronic TB risk questionnaire was used to identify people eligible for testing. The QIAreach QuantiFERON-TB essay was used for interferon gamma detection.

Results: A total of 107 workers out of 506 were eligible for testing, with a positivity rate of 50.47%. The main risk factor for latent tuberculosis was the contact with TB patients (59.26%). All positive cases were treated with weekly doses of Rifapentine/Isoniazid for 3 months (3HP). The treatment completion rate was 96.3%, and the most frequent adverse event was nausea. Sun exposure was correlated with a higher frequency of adverse effects, whereas the existence of a comorbidity appeared to be a protective factor.

Conclusion: Tuberculosis can be eradicated in Senegal with a low-cost strategy of identifying, screening, and treating people with latent tuberculosis infection. Our experience has proven to be acceptable and compliant with the weekly Rifapentine/Isoniazid regimen for 3 months. These strategies should be supported by regional labor inspectorates and rolled out on a large scale by regional health departments across the country.