Skeletal muscle channelopathy are rare heterogeneous episodic disorders with marked genotypic and phenotypic variability resulting in periodic paralysis, falls in young people, which often misdiagnosed or undiagnosed due to its rarity often. The symptoms are miscommunicated to the treating physician due to its episodic nature and not uncommonly physical examination by the time patient attend the clinic or hospital will be unremarkable apart from periodic muscle paralysis where patient will presented to ED with flaccid weakness. In this review we will present two patients where the diagnosis was initially missed and it took some time to reach the correct diagnosis.