Complications arising from Kidney damage and other renal pathologies have been a subject of major concern, which have been attributed to various sources. Concerns for patients with renal disease prompted the need for this study. We evaluated nitrogenous product levels on control (normal) subjects and those with dysfunction. Using spectrophotometric approach, we determined levels of creatinine, Urea, uric acid and some other parameters in four categories of patients. We observed a consistent elevated pattern of the parameters measured with severity of the status of the kidney dysfunction. A four-fold increase in concentration of the metabolites analyzed was observed in tandem with the respective disease condition. Values obtained necessitate the need for sustained laboratory investigation for early detection of those at risk to restore and mention homeostasis.