Canine transmissible venereal cancer (CTVT) is a transmissible cancer affecting dogs worldwide. It has the unique structural and functional capacity to be implanted from a carrier individual to a susceptible one to colonize a new anatomical niche. CTVT establishment depends on several factors including nutritional status, age and whether the dog is in a street situation or not. Here, we describe the CTVT generalities and the clinical management for a pregnant female dog with canine transmissible venereal tumor and propose an algorithm for clinical decision. The outcome of the proposed therapeutic management was the full clearance of the tumor with no relapse.