Research Article

Vitamin B12 Supplementation and Treatment in Cancer Patients: A Narrative Review

Authors: Emmanuel Andres, Noel Lorenzo-Villalba.

DOI: 10.33425/2639-8478.1118

---

Abstract

Vitamin B?? (cobalamin) deficiency is frequent in oncology, resulting from nutritional deficits, malabsorption, drug interactions, and tumor-related mechanisms. Correction of deficiency is crucial to prevent hematologic, neurologic, and nutritional complications and to optimize tolerance to chemotherapy, especially antifolates such as pemetrexed. This review summarizes recent evidence on the prevalence, mechanisms, diagnosis, and clinical management of vitamin B?? deficiency in cancer patients, including supplementation strategies and safety considerations.

View / Download PDF