Cardiology & Vascular Research
Open AccessThe Relationship Between Lipoprotein A and Glycosylated Hemoglobin and The Degree of Coronary Artery Stenosis in Non-Diabetic Coronary Heart Disease Patients
Authors: Wangzhou, Chen Xuejin, Qi Chunmei, Wang Lele, Sun Hua Mei, Wu Jing Yu, Fan Xiao Dan, Jin Jing Jing, Dai Ya Nan.
Abstract
Objectives: To explore the relationship between lipoprotein a (Lp (a)), glycosylated hemoglobin (HbA1c) and coronary stenosis in patients with non - diabetic coronary heart diseases.
Methods: A total of 302 patients with non-diabetic coronary heart disease were randomly selected from January 2018 to February 2019 in the department of cardiology of our hospital according to the random number table method. Biochemical, electrocardiogram and other relevant test results as well as general characteristics such as address, sex and age of the selected patients were recorded. Serum levels of Lp (a) and HbA1c were determinate and analyzed by One-way Anova to explore the correlation between them and the degree of coronary artery diseases.
Results: One-way Anova indicated that there were significant differences of coronary Gensini score among different serum level of Lp (a) groups.However, there was no statistically significant difference in the coronary Gensini score among the three groups of patients with different serum HbA1c levels (P=0.500).Spearman correlation analysis showed that coronary Gensini score was positively correlated with Lp (a) (r=0.284, P < 0.001). There was no significant relationship between coronary Gensini score and HbA1c (P=0.500). There was no correlation between HbA1c and Lp (a) (r=0.103, P=0.075).
Conclusion: HbA1c level has no obviously the correlation with the degree of coronary artery stenosis, but Lp (a) level is positively correlated with the degree of coronary artery stenosis and has a predictive value for the degree of coronary artery disease in non - diabetic CHD individuals.
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