This study was aimed at determining the effect of aqueous seed extract of Parkia biglobosa on the histology of the epidydimis of male wistar rats was studied. Twenty-one adult wistar rats weighing about 90-120g were use for this research work and were divided into three groups of 7 animals each. The control group was giving normal rat feed and water, the low dose group was administered (300mg/kgBw) of Parkia biglobosa extract and the high dose group was administered (500mg/kg) of the test substance. All extract were given daily by oral gavage method for thirty-one days. Twenty-four hours after the last administration, the animals in all the groups were sacrificed using cervical dislocation. The epidydimis were harvested, preserved, and fix in 10% buffer formalin and processed for hematoxylin and eosin (H&E) staining and periodic acid-Schiff (PAS) staining methods for glycogen distribution. The result of the study shows a (P<0.05) significant increase in the final body weight of the treated animals when compared with their initial body weight. The histological observation showed normal cytoarchitecture of the epididymis in the Control group. There was observable pathological appearance in the epididymis of the low dose group. However, there were prominent distortions in the high dose animals that received 500mg/kgBw of the extract. Histochemical observation shows a moderate PAS staining in the control group. While the treated groups reveals mildly stained cytoarchitechture of the epididymis.