Research Article

Balancing Immunity with a Dietary Supplement Derived from Five Edible Plants for Management of Diabetes

Authors: Sirithip Wiriyachitra, Pichaet Wiriyachitra, Ampai Panthong

DOI: 10.33425/2639-8494.1061

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Abstract

This study investigates the immunomodulatory effects of Diabenox/BIM-D, a dietary supplement derived from
five edible plants, namely black sesame, guava fruit, mangosteen aril, pennywort leaves, and soy protein, on the
regulation of T helper cell subpopulations. Twelve healthy volunteers were divided into two groups, one receiving a
placebo and the other taking Diabenox/BIM-D capsules for 15 days. Blood samples were collected before and after
the supplementation period, and peripheral blood mononuclear cells (PBMCs) were isolated and stimulated to assess
cytokine production.
In the present study, we demonstrated that Diabenox/BIM-D can modulate the immune cell functions by reducing the
production of pro-inflammatory cytokines, including TNF-α, IL-5, IL-12 and IL-17. Diabenox/BIM-D is therefore
suggested as the food supplement for balancing immunity in the management of diabetic patients.

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