Alzheimer's Disease (AD) remains a critical neurodegenerative challenge. This study evaluates BIM AD®, an improved formulation containing Fortified Mangosteen Extract, for its potential in preventing and slowing AD progression. We assessed stem cell markers, inflammatory cytokines, autophagy-related genes, telomere length, gene expression changes, T cells, and AD-related biomarkers in participants at baseline and at follow-up intervals of weeks 4 and 8. Supplementation with BIM AD® at 6 capsules/day in 8 participants for 8 weeks significantly increased the expression of stem cell-associated markers, stemness-related transcription factors, and CD34 counts. Immunological analysis revealed a significant decrease in pro-inflammatory cytokines (interleukin-17A [IL-17A] and TNF-α), alongside increased levels of FOXP3 and IL-10, and enhanced natural killer T cell activity, indicated by elevated IFN-γ. Furthermore, the formulation stimulated cellular recycling through autophagy-related genes, leading to telomere lengthening via new stem cell stimulation, and significantly reduced AD-specific pathology, notably p-tau 217 and the p-tau 181/t tau ratio. In conclusion, BIM AD® is beneficial for remedying AD, as well as inflammation and degeneration in all systems of the body.