Research Article

Effects of BIM Mangosteen Juice on Healthspan

Authors: Pichaet Wiriyachitra, Preeya Leelahagul, Ramida Watanapokasin, Sirithip Wiriyachitra, Jannatthabhorn Janprasert, Sakda Sreesangkom

DOI: 10.33425/2639-8494.1071

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Abstract

Daily consumption of 200 mL of BIM (Balancing Immunity) mangosteen juice (80% w/w) by 14 female participants over a 4-week period resulted in a reduction in pro-inflammatory cytokines, namely tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-17A (IL-17A), along with an increase in the anti-inflammatory cytokine interleukin-10(IL-10), which is associated with regulatory T cells. In addition, participants exhibited evidence of anti-aging and age- reversal effects, corresponding to an average estimated biological age reversal of approximately 1 year on average, with a maximum of 4 years, as indicated by telomere elongation and enhanced autophagy-related gene expression. These findings support the regimen of combining Mylife® capsules with BIM mangosteen juice. Furthermore, we found conclusive evidence that participants who consumed BIM mangosteen juice alone experienced increased autophagy. This investigation indicates the efficacy of BIM mangosteen juice in balancing immune responses in individuals with excessive elevation of Th17 resulting from Mylife® capsule consumption.

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