Research Article

Features of Antibiotic Resistance in Uncomplicated Urinary Tract Infection in Children and Effectiveness of Immunoprophylaxis

Authors: Stoieva T.V, Gruzievskyi O.A

DOI: 10.33425/2639-8494.1022

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Abstract

Background: The relapsing course of urinary tract infections (UTI) is an important issue. Repeated courses of antibiotics contribute to selection of multi-resistant microorganisms. Obviously, a new way of prevention, such as vaccination, has to be introduced.
Objectives: The purpose of this study was to evaluate the effectiveness of oral vaccination with a complex of frozen lyophilized microorganisms — Escherichia coli, Enterococcus faecalis, Proteus mirabilis, Klebsiella pneumoniae, Pseudomonas aeruginosa, Propionibacterium acnes for the prevention of recurrent UTI in children.
Methods: The study involved 30 children aged 7 to 16 years with an uncomplicated course of UTI and a frequency of 3 or more episodes per year. The study found that pathogens of uncomplicated UTI were E. coli (66.7%), Enterobacter aer., Enterococcus faecalis, Enterococcus spp., Proteus mirabilis, Proteus vulgaris, S. hominis, Streptococcus haemolyticus. Several pathogens were observed in 10% of patients, the presence of polymycrobial microflora correlated with the frequency of UTI (χ2 = 3.84, p

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