Research Article

Regenerative Innovation from Fortified Mangosteen Extract

Authors: Pichaet Wiriyachitra, Preeya Leelahagul, Ramida Watanapokasin, Sirithip Wiriyachitra, Jannatthabhorn Janprasert, Sakda Sreesangkom.

DOI: 10.33425/2639-8494.1068

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Abstract

This article describes a clinical study on a newly developed formulation, Fortified Mangosteen Extract, involving 19 participants, with the specific aim of investigating alterations in their T cells, cytokines, telomeres and autophagy. The results show that the formulation had no effect on the number of white blood cells related to immunity but caused a decrease in pro-inflammatory cytokines, TNF-α, IL-6, IL-17A, IL-12/IL-23 (p40), and IFN-γ, while increasing the level of IL-10 that regulates other pro-inflammatory cytokines. It also slowed telomere shortening in 6 participants and lengthened telomeres in 13 participants, demonstrating its anti-aging and age-reversal effects, respectively. Most importantly, the formulation induced autophagy-related gene expressions, LAMP1, LC3A, ATG5 and BECN1, during the study. In conclusion, this study clearly demonstrates the health benefits of Fortified Mangosteen Extract for individuals with autoimmune diseases, particularly its potential in the prevention and treatment of Alzheimer’s disease.

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