Research Article

Study of IL-4 and IL-6 Levels and Complement Activity Comparatively in Blood and Lymph in Experimental Anaphylactic Shock and Arthus Phenomenon

Authors: Alieva Tarana Rzakuli, Arzu Ibishova Vagif Kizi, Isazade Vugar Anar Oglu, Yaqubova Samira Mammadhasan Kizi.

DOI: 10.33425/2639-8494.1050

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Abstract

The levels of interleukins IL-4 and IL-6 and the activity of complement in blood and lymph were studied in experimental anaphylactic shock and the Arthus phenomenon. The experiments were carried out on 27 Winstar rats in two series. The studied parameters of interleukins IL-4 and IL-6 and complement activity in the blood and lymph of intact animals served as control. The results of the study showed that the level of IL-4 in anaphylactic shock increases and IL-6 decreases. On the other hand, with the Arthus phenomenon, the level of IL-6 increases, IL-4 decreases. The titer of complement in atopic reactions sharply decreases, and it indicates the participation of complement together with IgG in the elimination of the allergen. In immunocomplex reactions, the complement titer also decreases.

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