The primary focus of this article is to illustrate how Milton Erickson M.D.’s consciousness of appreciation reflected in his resistance protocol advanced the integration of clinical hypnosis with Quantum Physics. Numerous examples will be provided that show how Erickson’s interventions had parallels with the major quantum variables and concepts. Erickson’s appreciation of inferences, opposites, and frame of reference will be highlighted in his utilization of time in his treatment interventions. A review of efforts to integrate Quantum Physics with Psychology will emphasize the overlaps between Erickson and the French mathematician and physicist Poincare in terms of the value of the unconscious, time and permission. Time’s role in the evolution of hypnosis and Quantum Physics will complement the integration section. The implied directive will be explored in the context of it being a subset of the general set of all inferences. A detailed summary will be provided of the inferences operating in a hypnotherapeutic setting in terms of their value in facilitating bridges to novelty, ‘yes sets’ and the creative focusing of attention.