As rotator cuff related shoulder pain is quite prevalent, it is important that doctors continue to look for new treatment modalities, which are safe and effective. Over the last decade, isotonic glucose (or dextrose) injections have received more attention among clinicians. Unfortunately, no large randomized clinical trials have confirmed their effectiveness so far. However, their safety profile is very likely to be much better than subacromial corticosteroid injections. This article invites the medical community for further basic-science and clinical studies to investigate the potential benefits of local isotonic glucose injections for rotator cuff related shoulder pain. The goal of introducing the term Glucopuncture is to explain the difference with prolotherapy, to inform doctors about the interesting riskbenefits ratio of these regional isotonic glucose injections and to invite them to use these sugar water injections instead of cortisone injections.