Many patients with atopic dermatitis have not only skin but also multiple organ disorders such as intestinal tract and cervical spine. As the cause, the involvement of a toxin (called superantigen) produced by Staphylococcus aureus, which is detected from the skin of atopic dermatitis, is presumed. As a measure against Staphylococcus aureus, the use of Povidone-iodine was listed as adjuvant therapy in the Japanese Guidelines for Atopic Dermatitis Treatment 2018. In the future, we would like to treat atopic dermatitis as a superantigen disease and propose that Povidone-iodine solution be used in combination with general treatment as a measure against Staphylococcus aureus.