Cutaneous small vessel Vasculitides often manifest as hemorrhagic bullae and ulcers that take a chronic course and develop into necrotizing vasculitis with multiple infections. While the treatment of cutaneous Vasculitides has been focused on systemic immunosuppressive therapy and local care, studies have shown that chronic ulcers of various etiologies, can be successfully treated with ozone therapy. We report the case of a 67-year-old man who developed necrotizing leukocytoclastic vasculitis following the Covid-19 vaccination, along with deep tissue infection. 2 months of daily local ozone therapy with bag as well as ozone autohemotherapy twice weekly, resulted in complete resolution of the infected wounds.