Diabetes mellitus is a progressive chronic disease associated with enhanced levels of fasting glucose and HbA1C. Despite valuable recommendations of adopting healthy diet and lifestyle, and reducing exposure to environmental toxins, the risk of developing diabetes type II continues to increase. Internal stressors which increased the risk of developing diabetes type II include oxidative stress, chronic inflammation, intestinal dysbiosis, dysfunctional omega-, oxidative damage to insulin receptors, and increased activity of DPP-4 enzyme which blocks the secretion of insulin from the pancreas to the blood. Addressing one of these defects at a time may not be effective in reducing the risk of diabetes type II. To prevent the risk of diabetes type II, this review proposes to (a) adopt healthy diet and lifestyle and reduce exposure to environmental toxins, (b) supplement with a micronutrient mixture which would simultaneously reduce oxidative stress and chronic inflammation (c) probiotics with prebiotics which would reverse the harmful effects of intestinal dysbiosis, (d) omega-3 to replace oxidized dysfunctional omega 3 and in patients with insulin resistance would directly activate the insulin receptor-linked signaling protein AKT leading to the entry of glucose inside the cells, and (e) collagen peptides containing inhibitor of DPP4 which would increase the secretion of insulin from the pancreas to the blood. Despite diabetic medications, complications such as retinopathy, nephropathy, peripheral neuropathy, and heart disease continue to develop due to resistance to medications. The proposed prevention plan in combination with current treatments may improve and prolong their effectiveness and reduce the rate of progression of the dieses.