The article presents literature review (web-site PubMed is used) on the use of gentamicin-impregnated collagen matrices in prevention and treatment of surgical site infections – background information, clinical and pharmacological reasoning of the use of this composite product, clinical efficiency. Meta-analysis of published research on the application of this product in treatment of patients with diabetic foot syndrome has been carried out. The authors analyzed the results of their own research of topical application of antibiotic-impregnated collagen matrices in surgical treatment of 161 patients with diabetic foot syndrome and Charcot foot in purulent stage and with osteomyelitis.