Objective: This study aimed to study the antidiabetic effect of some Sudanese plants used traditionally by diabetic patients in Khartoum state, Sudan. The problem of this study lied under that Sudanese diabetic patients using some Sudanese medicinal plants without knowing their pharmaceutical effect and their recommended dose.

Materials & Methods: Twenty four albino rats were used in this study, All groups were loaded with 5% glucose (2gm/kg-body weight) after eighteen hours fasting, to induce diabetes, blood samples were taken to investigate blood glucose level, animals with blood glucose (70-110mg/dl) were served as control group (1) (N=6), animals with blood glucose levels higher than 120mg/dl were diagnosed as diabetic, groups (2, 3 and 4). then were administered with Cinnanomum zeylenicum (Girfa) aqueous extract (200, 400 and 800mg/kg-body weight) respectively, Blood specimens were collected from each group and serum levels of blood glucose, cholesterol and α-amylase concentrations were estimated.

Result: The results obtained from this study showed that there was a significant difference between treated groups which were administered with different doses of Cinnanomum zeylenicum (Girfa) aqueous extract and control group in blood glucose, cholesterol and α-amylase concentration.

Conclusion: It can be concluded from this study that Cinnanomum zeylenicum (Girfa) had hypoglycemic and hypocholesterolemic effect with no side effect. Furthermore, α-amylase concentration decreased with increasing the dose of Cinnanomum zeylenicum (Girfa) aqueous extract.