Diabetes Mellitus and Hypertension are two non-communicable diseases that are known to be very common with increasing morbidity and mortality rate. Complications arising from Diabetes and Hypertension have raised great concerns and especially for those in Comorbid condition. We assessed the electrolyte profile of patients in the different condition and in Comorbid State. Electrolytes Sodium, Potassium, Chloride and Bicarbonate were determined using Ion Specific Electrode from serum sample of patients. Data was analyzed with two-way analysis of variance (ANOVA). At P value of <0.05 as our confidence limit we observed a significant difference between controls and patients for all conditions except bicarbonate in comorbid. The findings are suggestive of Electrolyte imbalance that must be incorporated into our management schedule of diagnosis for these conditions.