Cases of neonatal jaundice due to Hyperbilirubinemia abound with some resulting in mortality especially arising from complications in Ceaserean Section. We studied biochemical patterns of some enzymes, hormones and other parameters in 1 - 4 days old neonates. Using spectrophotometnc and radioimmunoassay techniques we measured biochemical liver function parameters bilirubin, transaminases and gammaglutamyltransferase. Hormonal evaluation included cortisol, glucagon and adrenocortical hormone. Using SPSS version 23, paired sample test at 95% confidence intervals of difference shows 2 tail significance for bilirubin, transaminase; giucagon, cortisol and ACTH. Paired sample correlation also showed strong negative pattern with days. We conclude that the interplay of nervous system and self-regulating influence of stress hormones coupled with an immature liver triggers the formation of excess bilirubin.