Study was carried out to evaluate levels of Malondialdehyde and lipid profile parameters of some women in different phases of menstrual cycle. All subjects were premenopausal within childbearing age between 18 years to 50 years who had normal 28 days cycle. Blood samples were collected at follicular, ovulatory and luteal phase and their lipid profile and Malondialdehyde levels were determined spectrophotometrically. Applying analysis of variance with P value at (P<0.05) cholesterol and low-density lipoprotein showed significant difference at follicular and luteal phases. Marked variation was observed in all three phases for malondialdehyde with a peak at ovulatory phase. Pattern of result could be used to explain the interplay of lipids and hormonal behavior in menstruation.