Basidiobolus ranarum (B.Ranarum) is a fungus that causes an extremely rare condition known as gastrointestinal basidiobolomycosis (GIB). Human infection with B. Ranarum is described only in a few countries worldwide. We reported a 40-year-old female presented with persistent diarrhea and abdominal pain. A colonoscopy revealed cecal inflammation and ulcerations. Ultimately, a diagnosis of (GIB) was confirmed by a tissue biopsy obtained by colonoscopy, and antifungal therapy led to complete recovery without need for sugical intervention. This case contributes valuable insights to the limited literature on GIB and highlights the importance of prompt diagnosis and management in conditions that mimic more common diseases.